Title: (Senior) Scientist, Cardiovascular Diseases
Location: Manhattan, NY
Salary: $125,000-$145,000
Overview:
EPM is currently partnered with clinical stage biopharmaceutical company with an exciting pipeline that shows preclinical promise in a broad range of clinical indications. Two lead assets are currently in early phase clinical developments, and on track for further clinical development this year.
The leadership team brings over 25 years of success, with FDA-approved therapies, IPO launches, and multiple strategic biotech exits, along with deep connections across life sciences and venture ecosystems. Backed with resourceful funding and high-value partnerships in biotech and top-10 pharma, the company is well-positioned to reinvest into R&D, while advancing their current clinical pipeline in CNS and Fibrotic indications. They have identified that their platform naturally aligns with cardiovascular biology and are expanding into this area to drive the next wave of first-in-class therapies
Key Responsibilities:
- Lead target discovery, identification, and validation efforts focused on cardiovascular and cardiometabolic diseases, leveraging a cutting-edge small molecule discovery platform.
- Design and execute in vitro and cell-based assays to interrogate target biology, disease-relevant pathways, and compound activity across cardiovascular indications (e.g., atherosclerosis, vascular remodeling, heart failure, and fibrosis).
- Collaborate cross-functionally with chemistry, translational, and clinical teams to ensure alignment between discovery biology and downstream development strategies.
- Apply deep knowledge of vascular biology, endothelial dysfunction, inflammation, and metabolic signaling to guide biological validation of new targets.
- Analyze and interpret complex data sets, integrating findings into broader disease biology and drug discovery programs.
- Contribute to the development of the cardiovascular research strategy, incorporating new technologies, disease models, and biomarker approaches to support target prioritization and lead optimization.
- Stay current with emerging science and competitive landscape in cardiovascular and cardiometabolic drug discovery, providing scientific insights to shape pipeline expansion.
Key Skills & Qualifications:
- PhD in Cardiovascular Biology, Vascular Biology, Pharmacology, or a related discipline, with 3+ years of relevant industry experience(open to strong postdocs looking to transition).
- Deep expertise in cardiovascular disease biology, including knowledge of vascular dysfunction, endothelial biology, cardiomyocyte biology, cardiac fibrosis, and metabolic signaling.
- Hands-on experience with target discovery techniques such as:
- CRISPR screening
- RNA sequencing & omics data interpretation
- Biochemical and cellular assays to study target function (reporter assays, phenotypic screening, pathway modulation).
- Strong foundation in in vitro pharmacology- assay development, compound profiling, and mechanism-of-action studies for small molecules.
- Ability to work in a highly collaborative environment, communicating effectively with medicinal chemists, translational biologists, and external partners.
- Experience working within a small to mid-sized biotech environment is a plus - comfort operating in a fast-paced, evolving R&D setting.
- Passion for cardiovascular discovery and desire to play a hands-on role in shaping pipeline strategy in an innovative biotech setting.
